Sources

Home
1. Brien Holden Institute data on file, 2010
2. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfMAUDE/TextResults.cfm
3. https://www.health.com/eye-health/blue- light-eye- strain
4. Xu L, Wang Y, Wang S, Wang Y & Jonas JB, ‘High Myopia and Glaucoma Susceptibility: TheBeijing Eye Study’ Ophthalmology, Volume 114, Issue 2, February 2007; Praveen MR,Shah 5, GD, Vasavada AR, Mehta PG, Gilbert C & Bhagat G ‘A study to explore the risk factors for the early onset of cataract in India’, Eye, 24,
5. FDA Approval, 2002
6. Paragon Vision Sciences, Data on file, 2017
7. FDA Study, 2002
8. Vitale S, Sperduto RD, Ferris FL 3rd. Increased Prevalence of Myopia in the U.S. between
1971-1972 and 1999-2004. Arch Ophthalmol. 2009 Dec;127(12):1632-9. PubMed
9. Brien Holden Institute data on file, 2010
Back To School with Paragon CRT®
1: Pan C-W, Ramamurthy D, Saw S-M. Worldwide prevalence and risk factors for myopia. Ophthalmic and Physiological Optics. 2012;32(1):3-16.
2: FDA Approval study 2002
3: Dias, L., Manny, R. E., Hyman, L., & Fern, K. (2002). The Relationship between Self-Esteem of Myopic Children and Ocular and Demographic Characteristics. Optometry and Vision Science, 79(11)
4: Lipson, M.J., & Mcalinden, C. (2017). Orthokeratology and Contact Lens Quality of Life Questionnaire (OCL-QoL). Eye & contact lens Vol. 0, Num. 0.
5: Holden BA, Jong M, Davis S, Wilson D, Fricke T, Resnikoff S. (2005) Nearly 1 billion myopes at risk of myopia-related sight-threatening conditions by 2050 – time to act now. Clin Exp Optom. 2015 Nov;98(6):491-3.

Myopia Epidemic
1. Brien Holden Institute data on file, 2010
2. Xu L, Wang Y, Wang S, Wang Y & Jonas JB, ‘High Myopia and Glaucoma Susceptibility:The Beijing Eye Study’ Ophthalmology, Volume 114, Issue 2, February 2007; Praveen MR,Shah GD, Vasavada AR, Mehta PG, Gilbert C & Bhagat G ‘A study to explore the risk factors for the early onset of cataract in India’, Eye, 24,
3-5. Brian Holden Institute data on file, 2010
6. Pan C-W, Ramamurthy D, Saw S-M. Worldwide prevalence and risk factors for myopia. Ophthalmic and Physiological Optics. 2012;32(1):3-16.
7. Ophthalmic and Physiological Optics. 2012;32(1):3-16.
CRT Lenses
1. FDA Approval study 2002
2 Paragon vision Sciences data on file 2017
3. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfMAUDE/TextResults.cfm
4. Paragon CRT® Package Insert, 2016
5. Brien Holden Institue data on file, 2010

Clinical Studies
1. The Children’s Overnight Orthokeratology, Investigation (COOKI) Pilot Study JEFFREY J. WALLINE, OD, PhD, FAAO, MARJORIE J. RAH, OD, PhD, FAAO, and LISA A. JONES, PhD, FAAO. OPTOMETRY AND VISION SCIENCE, 2004
2. Paragon CRT® Contact Lenses Clinical Study, April 2002
Lifestyle Clubs
1. Nery García Porta, Laura Rico del Viejo, Alba Martin Gil, Gonzalo Carracedo, Jesus Pintor, José Manuel González Méijome, BioMed Research International, Differences in Dry Eye Questionnaire Symptoms in Two Different Modalities of Contact Lens Wear: Silicone-Hydrogel in Daily Wear Basis and Overnight Orthokeratology, Vol. 2016, Art. ID 1242845. 9 Pages.
What is Myopia
1. Holden BA, Fricke TR, Wilson DA, Jong M, Naidoo KS, Sankaridurg P, Wong TY, Naduvilath TJ, Resnikoff S, “Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050, Ophthalmology, May 2016 Volume 123, Issue 5, Pages 1036-1042
2. Huang, H., Shuo-The Chang, D., & Wu, P. (2015, October 20). The Association between Near Work Activities and Myopia in Children – A Systematic Review and Meta-Analysis [Review]. Plos One. Retrieved April 9, 2019 from https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140419
3. X. Z., Pardue, M. T., Iuone, O. & QU, J. (2017). Dopamine signaling and myopia development: What are the key challenges. Progress in Retinal and Eye Research, 61, 60-71. Retrieved December 20, 018 from https://www.sciencedirect.com/science/article/pii/S1350946217300101?via=ihub#!

See Your Life Without Limits
1. FDA Approval Letter
2. Accounting Letter from internal CRT System – total lenses sold since 2002, 8/14/15
3. Paragon Vision Sciences, Consumer Survey, Data on File, Oct 2018
Quality of Life
1. F. Z., G. Z., & Z. Z. (2018). Investigation of the Effect of Orthokeratology Lenses on Quality of Life and Behaviors of Children. Contact Lens Association of Ophthalmologists, Inc., 44(5). Retrieved May 8, 2019.
2. Lipson, M. (2019, June 12). Personal interview.

97% Satisfied Patients
1. Paragon Vision Sciences, Consumer Survey, Data on File, July 2019
2. FDA Approval Letter